DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D1) is a gene that encodes for a protein that functions as a component of an E3 ubiquitin ligase complex. Missense mutations, synonymous mutations, and nonsense mutations are observed in cancers such as colon cancer, endometrial cancer, and stomach cancer.
DCUN1D1 is altered in 0.99% of all cancers with squamous cell lung carcinoma, breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, conventional glioblastoma multiforme, and colon adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in DCUN1D1 are DCUN1D1 Amplification (0.69%), DCUN1D1 Loss (0.02%), DCUN1D1 R13C (0.01%), DCUN1D1 A235E (0.01%), and DCUN1D1 F18L (0.01%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.