Overview

Location [1]
6p21.33
Protein [2]
Epithelial discoidin domain-containing receptor 1
Synonyms [1]
HGK2, CD167, TRKE, RTK6, PTK3, MCK10, DDR, CAK, NTRK4, EDDR1, PTK3A, NEP

Discoidin domain receptor tyrosine kinase 1 (DDR1) is a gene that encodes a protein receptor tyrosine kinase that functions in the communication of cells with their microenvironment. The protein also regulates cell growth, differentiation, and metabolism. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

DDR1 is altered in 0.03% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial serous adenocarcinoma, and non-small cell lung carcinoma having the greatest prevalence of alterations [3].

DDR1 GENIE Cases - Top Diseases

The most common alterations in DDR1 are DDR1 Mutation (2.33%), DDR1-MDC1 Fusion (0.01%), DDR1 A533S (0.30%), DDR1 A98T (0.30%), and DDR1 D189G (0.30%) [3].

DDR1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.