Location [1]
Protein [2]
Endoribonuclease Dicer
Synonyms [1]
GLOW, HERNA, K12H4.8-LIKE, MNG1, DCR1, RMSE2, Dicer1e, Dicer

Dicer 1, ribonuclease type III (DICER1) is a gene that encodes a protein that functions as a ribonuclease. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as pleural cancer, pituitary cancer, and endometrial cancer.

DICER1 is altered in 2.44% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

DICER1 GENIE Cases - Top Diseases

The most common alterations in DICER1 are DICER1 Mutation (2.19%), DICER1 Amplification (0.09%), DICER1 D1709N (0.05%), DICER1 Loss (0.06%), and DICER1 E1705K (0.04%) [3].

DICER1 GENIE Cases - Top Alterations

Significance of DICER1 in Diseases

Melanoma +

Bladder Carcinoma +

Glioblastoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Anaplastic Astrocytoma +

Sarcoma +

Ovarian Carcinoma +

Head And Neck Carcinoma +

Breast Carcinoma +

Pancreatic Carcinoma +

Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.