Location [1]
Protein [2]
Exosome complex exonuclease RRP44
Synonyms [1]
2810028N01Rik, EXOSC11, RRP44, KIAA1008, dis3p

DIS3 is altered in 1.84% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

DIS3 GENIE Cases - Top Diseases

The most common alterations in DIS3 are DIS3 Loss (0.23%), DIS3 Amplification (0.18%), DIS3 D488N (0.05%), DIS3 R382Q (0.03%), and DIS3 R689Q (0.03%) [3].

DIS3 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.