Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
19p13.12
Protein [2]
DnaJ homolog subfamily B member 1
Synonyms [1]
RSPH16B, Hsp40, Sis1, HSPF1, Hdj1

DNAJB1 is altered in 0.36% of all cancers with fibrolamellar carcinoma, high grade ovarian serous adenocarcinoma, breast invasive ductal carcinoma, and hepatocellular carcinoma having the greatest prevalence of alterations [3].

DNAJB1 GENIE Cases - Top Diseases

The most common alterations in DNAJB1 are DNAJB1 Amplification (0.12%) and DNAJB1 Loss (0.02%) [3].

DNAJB1 GENIE Cases - Top Alterations

Significance of DNAJB1 in Diseases

Fibrolamellar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.