Location [1]
Protein [2]
DNA (cytosine-5)-methyltransferase 3B
Synonyms [1]

DNMT3B is altered in 1.90% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

DNMT3B GENIE Cases - Top Diseases

The most common alterations in DNMT3B are DNMT3B Mutation (1.07%), DNMT3B Amplification (0.69%), DNMT3B E674K (0.02%), DNMT3B A241T (0.01%), and DNMT3B Loss (0.01%) [3].

DNMT3B GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.