Biomarkers /

DOCK8

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Overview

Location [1]
9p24.3
Protein [2]
Dedicator of cytokinesis protein 8
Synonyms [1]
MRD2, ZIR8, HEL-205

DOCK8 is altered in 5.59% of all cancers with colon adenocarcinoma, lung adenocarcinoma, melanoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

DOCK8 GENIE Cases - Top Diseases

The most common alterations in DOCK8 are DOCK8 Mutation (4.81%), DOCK8 Loss (0.28%), DOCK8 T1968M (0.09%), DOCK8 Amplification (0.07%), and DOCK8 T1875I (0.09%) [3].

DOCK8 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.