Location [1]
Protein [2]
Dihydropyrimidine dehydrogenase [NADP(+)]
Synonyms [1]

Dihydropyrimidine dehydrogenase (DPYD) is a gene that encodes a protein is a pyrimidine catabolic enzyme. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as skin cancer, colon cancer, and stomach cancer.

DPYD is altered in 1.01% of all cancers with melanoma, breast invasive ductal carcinoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

DPYD GENIE Cases - Top Diseases

The most common alterations in DPYD are DPYD A356T (0.22%), DPYD A437T (0.85%), DPYD A777D (1.85%), DPYD A777S (1.85%), and DPYD A777Y (0.22%) [3].

DPYD GENIE Cases - Top Alterations

Significance of DPYD in Diseases

Colorectal Adenocarcinoma +

Intestinal Neoplasm +

Gastric Neoplasm +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.