Overview

Location [1]
5p13.3
Protein [2]
Ribonuclease 3
Synonyms [1]
HSA242976, RNASEN, RN3, RNASE3L, RANSE3L, ETOHI2

DROSHA is altered in 1.92% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

DROSHA GENIE Cases - Top Diseases

The most common alterations in DROSHA are DROSHA Mutation (1.77%), DROSHA Amplification (0.68%), DROSHA Loss (0.03%), DROSHA A1320V (0.02%), and DROSHA R801C (0.02%) [3].

DROSHA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.