Location [1]
Protein [2]
Dual specificity protein phosphatase 22
Synonyms [1]

Dual specificity phosphatase 22 (DUSP22) is a gene that encodes a protein that functions in the activation of the JNK signaling pathway. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

DUSP22 is altered in 0.09% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, mantle cell lymphoma, anaplastic large cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and follicular lymphoma having the greatest prevalence of alterations [3].

DUSP22 GENIE Cases - Top Diseases

The most common alterations in DUSP22 are DUSP22 Loss (0.26%), DUSP22 Amplification (0.24%), DUSP22 A23T (0.02%), DUSP22 Fusion (0.00%), and DUSP22 R147W (0.02%) [3].

DUSP22 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.