Overview

Location [1]
8p12
Protein [2]
Dual specificity protein phosphatase 4
Synonyms [1]
HVH2, MKP-2, TYP, MKP2

Dual specificity phosphatase 4 (DUSP4) is a gene that encodes a protein that belongs to the dual specificity protein phosphatase subfamily. The protein functions in the negative regulation of members of the mitogen-activated protein kinase family. The inactivation of these kinases is achieved by dephosphorylation. Fusions, missense mutations, silent mutations, nonstop extensions, and frameshift insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

DUSP4 is altered in 0.88% of all cancers with colon adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

DUSP4 GENIE Cases - Top Diseases

The most common alterations in DUSP4 are DUSP4 Loss (0.30%) and DUSP4 Amplification (0.03%) [3].

DUSP4 GENIE Cases - Top Alterations

Significance of DUSP4 in Diseases

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.