Location [1]
Protein [2]
Polycomb protein EED
Synonyms [1]

Embryonic ectoderm development (EED) is gene that encodes a protein that belongs to the Polycomb-group family. The protein contributes to the maintenance of the transcriptional repressive state of genes over successive cell generations. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

EED is altered in 0.85% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

EED GENIE Cases - Top Diseases

The most common alterations in EED are EED Mutation (0.52%), EED Amplification (0.21%), EED Loss (0.10%), EED R441* (0.02%), and EED A41T (0.01%) [3].

EED GENIE Cases - Top Alterations

Significance of EED in Diseases

Malignant Peripheral Nerve Sheath Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.