Associated Genetic Biomarkers
Embryonic ectoderm development (EED) is gene that encodes a protein that belongs to the Polycomb-group family. The protein contributes to the maintenance of the transcriptional repressive state of genes over successive cell generations. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.
EED is altered in 0.85% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in EED are EED Mutation (0.52%), EED Amplification (0.21%), EED Loss (0.10%), EED R441* (0.02%), and EED A41T (0.01%) .
EED status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EED status as an inclusion criterion, 1 is phase 2 (1 open).
Trials with EED status in the inclusion eligibility criteria most commonly target malignant peripheral nerve sheath tumor .
The most frequent alterations to serve as inclusion eligibility criteria are EED Loss and EED Mutation .
Decitabine and cedazuridine is the most frequent therapy in trials with EED as an inclusion criteria .
Significance of EED in Diseases
Malignant Peripheral Nerve Sheath Tumor +
EED is altered in 11.11% of malignant peripheral nerve sheath tumor patients .
EED is an inclusion criterion in 1 clinical trial for malignant peripheral nerve sheath tumor, of which 1 is open and 0 are closed. Of the trial that contains EED status and malignant peripheral nerve sheath tumor as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.