Overview

Location [1]
2p21
Synonyms [1]
M4S1, DIAR5, KS1/4, HNPCC8, ESA, EGP40, MIC18, TACSTD1, MK-1, KSA, EGP314, TROP1, EGP-2

Epithelial cell adhesion molecule (EPCAM) is a gene that encodes a protein that functions as a carcinoma-associated antigen. Missense mutations, silent mutations, nonsense mutations, and in-frame deletions are observed in cancers such as endometrial cancer, biliary tract cancer, and skin cancer.

Significance of EPCAM in Diseases

Malignant Solid Tumor +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Bronchogenic Carcinoma +

Central Nervous System Neoplasm +

Cervical Carcinoma +

Colorectal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Lung Carcinoma +

Lymphoma +

Malignant Uterine Neoplasm +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Soft Tissue Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.