Overview

Location [1]
1p36.13
Synonyms [1]
CTRCT6, CTPP1, ARCC2, CTPA, ECK

The EPH receptor A2 (EPHA2) gene is a member of the protein-tyrosine kinase subfamily of ephrin receptors and encodes a protein that associates with ephrin-A ligands. Missense mutations, nonsense mutations, silent mutations, and EPHA2 overexpression are observed in cancers such as biliary tract cancers, skin cancer, and stomach cancer.

Significance of EPHA2 in Diseases

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Lung Adenocarcinoma +

Malignant Glioma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Non-Small Cell Lung Carcinoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.