Location [1]
Protein [2]
Ephrin type-A receptor 2
Synonyms [1]

The EPH receptor A2 (EPHA2) gene is a member of the protein-tyrosine kinase subfamily of ephrin receptors and encodes a protein that associates with ephrin-A ligands. Missense mutations, nonsense mutations, silent mutations, and EPHA2 overexpression are observed in cancers such as biliary tract cancers, skin cancer, and stomach cancer.

EPHA2 is altered in 0.57% of all cancers.

The most common alterations in EPHA2 are EPHA2 Mutation (0.02%), EPHA2 A664A (0.00%), EPHA2 D76N (0.00%), EPHA2 G251G (0.00%), and EPHA2 G726V (0.00%) [3].

EPHA2 GENIE Cases - Top Alterations

Significance of EPHA2 in Diseases

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Lung Adenocarcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Non-Small Cell Lung Carcinoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.