EPH receptor A3 (EPHA3) is a gene that encodes a protein-tyrosine kinase in the ephrin receptor family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.
EPHA3 is altered in 3.29% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations .
The most common alterations in EPHA3 are EPHA3 Mutation (2.87%), EPHA3 Amplification (0.13%), EPHA3 Loss (0.10%), EPHA3 R136* (0.07%), and EPHA3 Fusion (0.15%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.