Location [1]
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Ephrin type-A receptor 3
Synonyms [1]

EPH receptor A3 (EPHA3) is a gene that encodes a protein-tyrosine kinase in the ephrin receptor family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

EPHA3 is altered in 3.29% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations [3].

EPHA3 GENIE Cases - Top Diseases

The most common alterations in EPHA3 are EPHA3 Mutation (2.87%), EPHA3 Amplification (0.13%), EPHA3 Loss (0.10%), EPHA3 R136* (0.07%), and EPHA3 Fusion (0.15%) [3].

EPHA3 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.