Overview

Location [1]
6q16.1
Protein [2]
Ephrin type-A receptor 7
Synonyms [1]
EK11, EHK3, EHK-3, HEK11

EPH receptor A7 (EPHA7) is a gene that encodes a protein-tyrosine kinase that is a member of the ephrin receptor subfamily. The protein functions in mediating developmental processes in the nervous system. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

EPHA7 is altered in 2.84% of all cancers with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

EPHA7 GENIE Cases - Top Diseases

The most common alterations in EPHA7 are EPHA7 Loss (0.33%), EPHA7 Amplification (0.05%), EPHA7 S225F (0.03%), EPHA7 R895* (0.03%), and EPHA7 R231* (0.03%) [3].

EPHA7 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.