Location [1]
Receptor tyrosine kinase/growth factor signaling
Protein [2]
ERBB4 intracellular domain
Synonyms [1]
p180erbB4, HER4, ALS19

Erb-b2 receptor tyrosine kinase 4 (ERBB4) is a gene that encodes a receptor tyrosine kinase in the epidermal growth factor family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

ERBB4 is altered in 2.85% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

ERBB4 GENIE Cases - Top Diseases

The most common alterations in ERBB4 are ERBB4 Mutation (4.15%), ERBB4 Loss (0.06%), ERBB4 Amplification (0.04%), ERBB4 E452K (0.03%), and ERBB4 T140A (0.03%) [3].

ERBB4 GENIE Cases - Top Alterations

Significance of ERBB4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Urothelial Carcinoma +

Oropharyngeal Carcinoma +

Malignant Glioma +

Malignant Hepatobiliary Neoplasm +

Hepatobiliary Neoplasm +

Pancreatic Carcinoma +

Gastrointestinal Stromal Tumor +

Astrocytoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Diffuse Intrinsic Pontine Glioma +

Ependymoma +

Head And Neck Squamous Cell Carcinoma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Medulloblastoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neuroblastoma +

Primitive Neuroectodermal Tumor +

Rhabdomyosarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.