Overview

Location [1]
2q34
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
p180erbB4, ALS19, HER4

Erb-b2 receptor tyrosine kinase 4 (ERBB4) is a gene that encodes a receptor tyrosine kinase in the epidermal growth factor family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of ERBB4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Astrocytoma +

Diffuse Intrinsic Pontine Glioma +

Ependymoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Glioma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Medulloblastoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neuroblastoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Primitive Neuroectodermal Tumor +

Rhabdomyosarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.