Overview

Location [1]
21q22.2
Protein [2]
Transcriptional regulator ERG
Synonyms [1]
erg-3, p55

V-ets avian erythroblastosis virus E26 oncogene homolog (ERG) is a gene that encodes a transcription factor protein in the erythroblast transformation-specific (ETS) family. The protein functions in embryonic development, cell differentiation, apoptosis, and many other cellular processes. Fusions, missense mutations, and silent mutations are observed in cancers such as lung cancer, ovarian cancer, and skin cancer.

ERG is altered in 1.00% of all cancers with prostate adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, bladder urothelial carcinoma, and Ewing sarcoma having the greatest prevalence of alterations [3].

ERG GENIE Cases - Top Diseases

The most common alterations in ERG are ERG Amplification (0.12%) and ERG Loss (0.03%) [3].

ERG GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.