Overview

Location [1]
17q21.31
Protein [2]
ETS translocation variant 4
Synonyms [1]
E1AF, PEAS3, PEA3, E1A-F

ETS variant 4 (ETV4) is a gene that encodes a transcription factor protein that is a member of the ETS (E twenty-six) family. The protein functions in the regulation of cell growth, angiogenesis, migration proliferation, and differentiation. Fusions, missense mutations, and silent mutations are observed in cancers such as ovarian cancer and cancers of the upper digestive tract.

ETV4 is altered in 0.58% of all cancers with lung adenocarcinoma, prostate adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

ETV4 GENIE Cases - Top Diseases

The most common alterations in ETV4 are ETV4 Mutation (1.05%), ETV4 Amplification (0.07%), ETV4 E30K (0.04%), ETV4 S127P (0.05%), and ETV4 Fusion (0.05%) [3].

ETV4 GENIE Cases - Top Alterations

Significance of ETV4 in Diseases

Gastric Adenocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.