Associated Genetic Biomarkers
ETS variant 4 (ETV4) is a gene that encodes a transcription factor protein that is a member of the ETS (E twenty-six) family. The protein functions in the regulation of cell growth, angiogenesis, migration proliferation, and differentiation. Fusions, missense mutations, and silent mutations are observed in cancers such as ovarian cancer and cancers of the upper digestive tract.
ETV4 is altered in 0.07% of all cancers.
The most common alterations in ETV4 are ETV4 Amplification (0.02%) and ETV4 Loss (0.00%) .
ETV4 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains ETV4 status as an inclusion criterion, 1 is phase 2 (0 open).
Trials with ETV4 status in the inclusion eligibility criteria most commonly target adenocarcinoma of the gastroesophageal junction and gastric adenocarcinoma .
The most frequent alteration to serve as an inclusion eligibility criterion is ETV4 Expression .
Docetaxel and selumetinib are the most frequent therapies in trials with ETV4 as an inclusion criteria .
Significance of ETV4 in Diseases
Adenocarcinoma Of The Gastroesophageal Junction +
ETV4 is an inclusion criterion in 1 clinical trial for adenocarcinoma of the gastroesophageal junction, of which 0 are open and 1 is closed. Of the trial that contains ETV4 status and adenocarcinoma of the gastroesophageal junction as inclusion criteria, 1 is phase 2 (0 open) .
Gastric Adenocarcinoma +
ETV4 is an inclusion criterion in 1 clinical trial for gastric adenocarcinoma, of which 0 are open and 1 is closed. Of the trial that contains ETV4 status and gastric adenocarcinoma as inclusion criteria, 1 is phase 2 (0 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.