Overview

Location [1]
3q27.2
Protein [2]
ETS translocation variant 5
Synonyms [1]
ERM

ETS variant 5 (ETV5) is a gene that encodes a transcription factor protein that is a member of the ETS (E twenty-six) family. The protein binds to DNA containing sequences that contain the nucleotide sequence GGAA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and urinary tract cancer.

ETV5 is altered in 0.19% of all cancers with squamous cell lung carcinoma and anal squamous cell carcinoma having the greatest prevalence of alterations [3].

ETV5 GENIE Cases - Top Diseases

The most common alteration in ETV5 is ETV5 Amplification (0.09%) [3].

ETV5 GENIE Cases - Top Alterations

Significance of ETV5 in Diseases

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.