Overview

Location [1]
1q43
Protein [2]
Exonuclease 1
Synonyms [1]
hExoI, HEX1

EXO1 is altered in 1.87% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

EXO1 GENIE Cases - Top Diseases

The most common alterations in EXO1 are EXO1 Mutation (0.28%), EXO1 Amplification (0.01%), EXO1 D462N (0.01%), EXO1 C508Lfs*7 (0.00%), and EXO1 D303E (0.00%) [3].

EXO1 GENIE Cases - Top Alterations

Significance of EXO1 in Diseases

Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Malignant Uterine Neoplasm +

Colorectal Carcinoma +

Breast Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bladder Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Melanoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.