Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Fanconi-associated nuclease 1
Synonyms [1]

FAN1 is altered in 2.43% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and glioblastoma having the greatest prevalence of alterations [3].

FAN1 GENIE Cases - Top Diseases

The most common alterations in FAN1 are FAN1 Mutation (2.05%), FAN1 P788S (0.09%), FAN1 V687I (0.06%), FAN1 Loss (0.04%), and FAN1 G580S (0.05%) [3].

FAN1 GENIE Cases - Top Alterations

Significance of FAN1 in Diseases

Breast Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.