Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
15q13.3
Protein [2]
Fanconi-associated nuclease 1
Synonyms [1]
hFAN1, MTMR15, KIAA1018, KMIN

FAN1 is altered in 2.24% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

FAN1 GENIE Cases - Top Diseases

The most common alterations in FAN1 are FAN1 Mutation (0.34%), FAN1 P788S (0.01%), FAN1 D873Tfs*17 (0.01%), FAN1 R12Gfs*45 (0.01%), and FAN1 V687I (0.01%) [3].

FAN1 GENIE Cases - Top Alterations

Significance of FAN1 in Diseases

Breast Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.