Overview

Location [1]
10q23.31
Pathway
Apoptosis
Protein [2]
Tumor necrosis factor receptor superfamily member 6
Synonyms [1]
CD95, FASTM, TNFRSF6, APT1, APO-1, ALPS1A, FAS1

Fas cell surface death receptor (FAS) is a gene that encodes a protein that belongs to the TNF-receptor superfamily. The protein functions in the physiological regulation of programmed cell death (apoptosis). The protein also plays a role in various diseases and malignancies of the immune system. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, hematopoietic and lymphoid cancers, and skin cancer.

FAS is altered in 1.28% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma, and follicular lymphoma having the greatest prevalence of alterations [3].

FAS GENIE Cases - Top Diseases

The most common alterations in FAS are FAS Loss (0.41%), FAS C135fs (0.05%), FAS V220fs (0.05%), FAS N223H (0.04%), and FAS G286E (0.04%) [3].

FAS GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.