Overview

Location [1]
4q35.2
Protein [2]
Protocadherin Fat 1, nuclear form
Synonyms [1]
CDHF7, CDHR8, hFat1, ME5, FAT

FAT atypical cadherin 1 (FAT1) is a gene that encodes a tumor suppressor protein that controls cell proliferation. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as colon cancer, endometrial cancer, and upper aerodigestive tract cancers.

FAT1 is altered in 5.88% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FAT1 GENIE Cases - Top Diseases

The most common alterations in FAT1 are FAT1 Mutation (5.69%), FAT1 Loss (0.46%), FAT1 R2597* (0.05%), FAT1 Fusion (0.25%), and FAT1 Amplification (0.03%) [3].

FAT1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.