Overview

Location [1]
1q23.3
Protein [2]
Low affinity immunoglobulin gamma Fc region receptor II-b
Synonyms [1]
FCGR2, CD32, CD32B, IGFR2, FCG2

Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B) is a gene that encodes a protein that functions as a low affinity receptor for the Fc region of immunoglobulin complexes. The protein plays a role in phagocytosis of immune complexes and regulation of antibody production by B-cells. Fusions mutations are observed in this gene.

Significance of FCGR2B in Diseases

Chronic Lymphocytic Leukemia +

Mantle Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.