Overview

Location [1]
6q27
Protein [2]
FGFR1 oncogene partner
Synonyms [1]
FOP

FGFR1 oncogene partner (FGFR1OP) is a gene that encodes a protein that functions as a hydrophilic centrosomal protein. The protein is necessary for anchoring microtubules to subcellular structures. Fusions, missense mutations, and nonsense mutations are observed in cancers such as intestinal cancer, ovarian cancer, and stomach cancer.

FGFR1OP is altered in 0.22% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, dysembryoplastic neuroepithelial tumor, high grade ovarian serous adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

FGFR1OP GENIE Cases - Top Diseases

The most common alteration in FGFR1OP is FGFR1OP-FGFR1 Fusion (0.22%) [3].

FGFR1OP GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.