Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
11q24.3
Protein [2]
Friend leukemia integration 1 transcription factor
Synonyms [1]
SIC-1, EWSR2, BDPLT21

Fli-1 proto-oncogene, ETS transcription factor (FLI1) is a gene that encodes a protein that functions as an ETS DNA-binding domain containing transcription factor. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, parathyroid cancer, and skin cancer.

FLI1 is altered in 0.88% of all cancers with sarcoma, colorectal adenocarcinoma, non-small cell lung carcinoma, prostate cancer, and head and neck cancer having the greatest prevalence of alterations [3].

FLI1 GENIE Cases - Top Diseases

The most common alterations in FLI1 are FLI1 G449D (0.00%), FLI1 Q370K (0.00%), FLI1 R68Q (0.00%), FLI1 T249M (0.00%), and FLI1 X277_splice (0.00%) [3].

FLI1 GENIE Cases - Top Alterations

Significance of FLI1 in Diseases

Ewing Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.