Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
11q24.3
Synonyms [1]
EWSR2, SIC-1, BDPLT21

Fli-1 proto-oncogene, ETS transcription factor (FLI1) is a gene that encodes a protein that functions as an ETS DNA-binding domain containing transcription factor. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, parathyroid cancer, and skin cancer.

Significance of FLI1 in Diseases

Ewing Sarcoma +

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.