Location [1]
Protein [2]
Forkhead box protein O1
Synonyms [1]

Forkhead box O1 (FOXO1) is a gene that encodes a transcription factor protein that functions in insulin signaling and the regulation of metabolic homeostasis in the presence of oxidative stress. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

FOXO1 is altered in 1.16% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, follicular lymphoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

FOXO1 GENIE Cases - Top Diseases

The most common alterations in FOXO1 are FOXO1 Mutation (0.85%), FOXO1 Loss (0.30%), FOXO1 Amplification (0.17%), FOXO1-FGFR1 Fusion (0.29%), and FOXO1 Fusion (0.11%) [3].

FOXO1 GENIE Cases - Top Alterations

Significance of FOXO1 in Diseases

Rhabdomyosarcoma +

Non-Hodgkin Lymphoma +

Soft Tissue Sarcoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.