Associated Genetic Biomarkers
Forkhead box O1 (FOXO1) is a gene that encodes a transcription factor protein that functions in insulin signaling and the regulation of metabolic homeostasis in the presence of oxidative stress. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
FOXO1 is altered in 1.20% of all cancers with breast carcinoma, colorectal adenocarcinoma, non-small cell lung carcinoma, lymphoma, and prostate cancer having the greatest prevalence of alterations .
The most common alterations in FOXO1 are FOXO1 Mutation (0.52%), FOXO1 Loss (0.19%), FOXO1 Amplification (0.10%), FOXO1 R214C (0.02%), and FOXO1 S22P (0.01%) .
FOXO1 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains FOXO1 status as an inclusion criterion, 1 is phase 3 (1 open).
Trials with FOXO1 status in the inclusion eligibility criteria most commonly target rhabdomyosarcoma .
The most frequent alteration to serve as an inclusion eligibility criterion is FOXO1 Fusion .
Cyclophosphamide, irinotecan, temsirolimus, and vincristine are the most frequent therapies in trials with FOXO1 as an inclusion criteria .
Significance of FOXO1 in Diseases
FOXO1 is mutated in 8.45% of rhabdomyosarcoma patients .
FOXO1 is an inclusion criterion in 1 clinical trial for rhabdomyosarcoma, of which 1 is open and 0 are closed. Of the trial that contains FOXO1 status and rhabdomyosarcoma as inclusion criteria, 1 is phase 3 (1 open) .
Cyclophosphamide, irinotecan, and temsirolimus are the most frequent therapies in rhabdomyosarcoma trials with FOXO1 alterations as inclusion criteria .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.