Associated Genetic Biomarkers
Forkhead box O1 (FOXO1) is a gene that encodes a transcription factor protein that functions in insulin signaling and the regulation of metabolic homeostasis in the presence of oxidative stress. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
FOXO1 is altered in 0.97% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, and diffuse large B-cell lymphoma having the greatest prevalence of alterations .
The most common alterations in FOXO1 are FOXO1 Mutation (0.52%), FOXO1 Loss (0.19%), FOXO1 Amplification (0.10%), FOXO1 R214C (0.02%), and FOXO1 S22P (0.01%) .
FOXO1 status serves as an inclusion eligibility criteria in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain FOXO1 status as an inclusion criterion, 1 is phase 2 (1 open) and 1 is phase 3 (1 open).
Trials with FOXO1 status in the inclusion eligibility criteria most commonly target rhabdomyosarcoma .
The most frequent alterations to serve as inclusion eligibility criteria are FOXO1 Fusion and PAX3-FOXO1 Fusion .
Cyclophosphamide, irinotecan, temsirolimus, and vincristine are the most frequent therapies in trials with FOXO1 as an inclusion criteria .
Significance of FOXO1 in Diseases
FOXO1 is altered in 5.83% of rhabdomyosarcoma patients .
FOXO1 is an inclusion criterion in 2 clinical trials for rhabdomyosarcoma, of which 2 are open and 0 are closed. Of the trials that contain FOXO1 status and rhabdomyosarcoma as inclusion criteria, 1 is phase 2 (1 open) and 1 is phase 3 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.