Biomarkers /
FOXP1
Overview
Forkhead box P1 (FOXP1) is a gene that encodes a transcription factor protein that functions in the regulation of tissue- and cell-type specific gene transcription. The protein is important during development and adulthood. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
FOXP1 is altered in 1.46% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, prostate adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in FOXP1 are FOXP1 Mutation (0.98%), FOXP1 Loss (0.16%), FOXP1 Amplification (0.11%), FOXP1 X511_splice (0.05%), and FOXP1 R514H (0.03%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.