Overview

Location [1]
12q15
Protein [2]
Fibroblast growth factor receptor substrate 2
Synonyms [1]
SNT-1, FRS1A, FRS2alpha, SNT, FRS2A, SNT1

Fibroblast growth factor receptor substrate 2 (FRS2) is a gene that encodes an adapter protein that links NGF and FGR receptors to downstream signaling pathways. The protein is also important for the activation of MAP kinases and PIK3R1. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

FRS2 is altered in 2.66% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, and ovarian neoplasm having the greatest prevalence of alterations [3].

FRS2 GENIE Cases - Top Diseases

The most common alterations in FRS2 are FRS2 Amplification (0.08%), FRS2 Mutation (0.04%), FRS2 E360K (0.00%), FRS2 E39* (0.00%), and FRS2 E408K (0.00%) [3].

FRS2 GENIE Cases - Top Alterations

Significance of FRS2 in Diseases

Malignant Solid Tumor +

Hepatocellular Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.