Associated Genetic Biomarkers
Fibroblast growth factor receptor substrate 2 (FRS2) is a gene that encodes an adapter protein that links NGF and FGR receptors to downstream signaling pathways. The protein is also important for the activation of MAP kinases and PIK3R1. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
FRS2 is altered in 0.78% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, dedifferentiated liposarcoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in FRS2 are FRS2 Mutation (0.94%), FRS2 Amplification (2.95%), FRS2 R273K (0.11%), FRS2 E264G (0.09%), and FRS2 Loss (0.19%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.