Overview

Far upstream element (FUSE) binding protein 1 (FUBP1) is a gene that encodes a protein that functions as a single stranded DNA-binding protein. The protein binds to several DNA elements, including FUSE located on c-myc. The protein regulates c-myc in undifferentiated cells. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, and frameshift deletions and insertions are observed in cancers such as cancers of the central nervous system, intestinal cancer, and cancers of the upper aerodigestive tract.

FUBP1 is altered in 1.17% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, oligodendroglioma, and anaplastic oligodendroglioma having the greatest prevalence of alterations [3].

The most common alterations in FUBP1 are FUBP1 Mutation (0.71%), FUBP1 Amplification (0.09%), FUBP1 Loss (0.06%), FUBP1 R430C (0.05%), and FUBP1 R344Q (0.01%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.