Overview

Location [1]
16p11.2
Protein [2]
RNA-binding protein FUS
Synonyms [1]
FUS1, TLS, POMP75, HNRNPP2, ETM4, ALS6

FUS RNA binding protein (FUS) is a gene that encodes a protein that functions of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The protein complex has a role in pre-mRNA splicing and the export of processed mRNA to the cytoplasm. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

FUS is altered in 0.09% of all cancers.

The most common alteration in FUS is FUS Amplification (0.03%) [3].

FUS GENIE Cases - Top Alterations

Significance of FUS in Diseases

Myxoid Liposarcoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor +

Round Cell Liposarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.