Location [1]
Protein [2]
RNA-binding protein FUS
Synonyms [1]

FUS RNA binding protein (FUS) is a gene that encodes a protein that functions of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The protein complex has a role in pre-mRNA splicing and the export of processed mRNA to the cytoplasm. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

FUS is altered in 0.69% of all cancers with lung adenocarcinoma, colon adenocarcinoma, myxoid liposarcoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FUS GENIE Cases - Top Diseases

The most common alterations in FUS are FUS Fusion (0.12%), FUS-DDIT3 Fusion (0.11%), FUS-ERG Fusion (0.07%), FUS-CREB3L2 Fusion (0.06%), and FUS-CREM Fusion (0.12%) [3].

FUS GENIE Cases - Top Alterations

Significance of FUS in Diseases

Myxoid Liposarcoma +

Ewing Sarcoma +

Sarcoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor +

Osteosarcoma +

Primitive Neuroectodermal Tumor +

Round Cell Liposarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.