Associated Genetic Biomarkers
FUS RNA binding protein (FUS) is a gene that encodes a protein that functions of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The protein complex has a role in pre-mRNA splicing and the export of processed mRNA to the cytoplasm. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
FUS is altered in 0.09% of all cancers.
The most common alteration in FUS is FUS Amplification (0.03%) .
FUS status serves as an inclusion eligibility criteria in 3 clinical trials, of which 3 are open and 0 are closed. Of the trials that contain FUS status as an inclusion criterion, 3 are phase 2 (3 open).
Trials with FUS status in the inclusion eligibility criteria most commonly target Ewing sarcoma/peripheral primitive neuroectodermal tumor .
The most frequent alterations to serve as inclusion eligibility criteria are FUS-DDIT3 Fusion and FUS Fusion .
Ganitumab and palbociclib are the most frequent therapies in trials with FUS as an inclusion criteria .
Significance of FUS in Diseases
Myxoid Liposarcoma +
FUS is an inclusion criterion in 2 clinical trials for myxoid liposarcoma, of which 2 are open and 0 are closed. Of the trials that contain FUS status and myxoid liposarcoma as inclusion criteria, 2 are phase 2 (2 open) .
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor +
FUS is an inclusion criterion in 1 clinical trial for Ewing sarcoma/peripheral primitive neuroectodermal tumor, of which 1 is open and 0 are closed. Of the trial that contains FUS status and Ewing sarcoma/peripheral primitive neuroectodermal tumor as inclusion criteria, 1 is phase 2 (1 open) .
Round Cell Liposarcoma +
FUS is an inclusion criterion in 1 clinical trial for round cell liposarcoma, of which 1 is open and 0 are closed. Of the trial that contains FUS status and round cell liposarcoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.