Overview

Location [1]
6q21
Protein [2]
Tyrosine-protein kinase Fyn
Synonyms [1]
SLK, p59-FYN, SYN

FYN proto-oncogene, Src family tyrosine kinase (FYN) is a gene that encodes a protein that functions as a membrane-associated tyrosine kinase that regulates cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FYN is altered in 1.12% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, and prostate cancer having the greatest prevalence of alterations [3].

FYN GENIE Cases - Top Diseases

The most common alterations in FYN are FYN Mutation (0.33%), FYN Loss (0.13%), FYN Amplification (0.07%), FYN E107Q (0.01%), and FYN X374_splice (0.01%) [3].

FYN GENIE Cases - Top Alterations

Significance of FYN in Diseases

Lymphoma +

Malignant Solid Tumor +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.