Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
7q21.13
Pathway
Beta-Catenin/WNT signaling
Protein [2]
Frizzled-1
Synonyms [1]
-

Frizzled class receptor 1 (FZD1) is a gene that encodes a protein that functions as a 7-transmembrane receptor protein for Wnt signaling proteins. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Significance of FZD1 in Diseases

Esophageal Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Colorectal Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Solid Tumor +

Melanoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.