Overview

Location [1]
17p13.1
Protein [2]
Growth arrest-specific protein 7
Synonyms [1]
-

Growth arrest-specific 7 (GAS7) is a gene that encodes a protein that functions in terminally differentiated brain cells and mature cerebellar Purkinje neurons. The protein also plays a small role in neuronal development. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as genital tract cancer, intestinal cancer, and stomach cancer.

GAS7 is altered in 0.04% of all cancers with lung adenocarcinoma, acute myeloid leukemia, bladder urothelial carcinoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

GAS7 GENIE Cases - Top Diseases

The most common alteration in GAS7 is GAS7-TP53 Fusion (0.00%) [3].

GAS7 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.