Overview

Location [1]
10p14
Protein [2]
Trans-acting T-cell-specific transcription factor GATA-3
Synonyms [1]
HDRS, HDR

GATA binding protein 3 (GATA3) is a gene that encodes a transcription factor protein that contains two zinc fingers. The protein functions in immune regulation by regulating T-cell development. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as biliary tract cancer, breast cancer, and intestinal cancer.

GATA3 is altered in 3.77% of all cancers with breast carcinoma, non-small cell lung carcinoma, melanoma, colorectal adenocarcinoma, and bladder carcinoma having the greatest prevalence of alterations [3].

GATA3 GENIE Cases - Top Diseases

The most common alterations in GATA3 are GATA3 Mutation (3.09%), GATA3 Amplification (0.53%), GATA3 Loss (0.30%), GATA3 P408Afs*99 (0.25%), and GATA3 D335Gfs*17 (0.12%) [3].

GATA3 GENIE Cases - Top Alterations

Significance of GATA3 in Diseases

Breast Carcinoma +

Malignant Solid Tumor +

Melanoma +

Bladder Carcinoma +

Glioblastoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Anaplastic Astrocytoma +

Lymphoma +

Sarcoma +

Pancreatic Carcinoma +

Head And Neck Carcinoma +

Ovarian Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.