Location [1]
Protein [2]
Trans-acting T-cell-specific transcription factor GATA-3
Synonyms [1]

GATA binding protein 3 (GATA3) is a gene that encodes a transcription factor protein that contains two zinc fingers. The protein functions in immune regulation by regulating T-cell development. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as biliary tract cancer, breast cancer, and intestinal cancer.

GATA3 is altered in 3.67% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, colon adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

GATA3 GENIE Cases - Top Diseases

The most common alterations in GATA3 are GATA3 Mutation (1.33%), GATA3 Amplification (0.47%), GATA3 Loss (0.40%), GATA3 X308_splice (0.43%), and GATA3 M293K (0.07%) [3].

GATA3 GENIE Cases - Top Alterations

Significance of GATA3 in Diseases

Breast Carcinoma +

Melanoma +

Glioblastoma +

Bladder Carcinoma +

Anaplastic Astrocytoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Malignant Solid Tumor +

Sarcoma +

Ovarian Carcinoma +

Lymphoma +

Head And Neck Carcinoma +

Pancreatic Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.