Location [1]
Protein [2]
Flap endonuclease GEN homolog 1
Synonyms [1]

GEN1 is altered in 1.45% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, endometrial endometrioid adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

GEN1 GENIE Cases - Top Diseases

The most common alterations in GEN1 are GEN1 Mutation (0.27%), GEN1 Frameshift (0.03%), GEN1 Nonsense (0.02%), GEN1 Amplification (0.01%), and GEN1 Deletion (0.01%) [3].

GEN1 GENIE Cases - Top Alterations

Significance of GEN1 in Diseases

Prostate Adenocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Prostate Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.