Overview

Location [1]
17p11.2|17p11.2
Protein [2]
Glucose-induced degradation protein 4 homolog
Synonyms [1]
VID24, C17orf39, VID2

GID complex subunit 4 homolog (GID4, also known as C17orf39) is a gene that encodes a protein that is thought to be a subunit of the Mediator complex, a coactivator of RNA polymerase II. Missense mutations, synonymous mutations, nonsense mutations, and frameshift insertions are observed in cancers such as endometrial cancer, colon cancer, and skin cancer.

GID4 is altered in 0.98% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, leiomyosarcoma, cutaneous melanoma, and esophageal adenocarcinoma having the greatest prevalence of alterations [3].

GID4 GENIE Cases - Top Diseases

The most common alterations in GID4 are GID4 Amplification (0.42%), GID4 H46P (1.11%), GID4 E30K (0.25%), GID4 L73F (0.13%), and GID4 A68dup (0.35%) [3].

GID4 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.