Location [1]
Protein [2]
Zinc finger protein GLI2
Synonyms [1]

GLI2 is altered in 3.26% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, breast invasive ductal carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

GLI2 GENIE Cases - Top Diseases

The most common alterations in GLI2 are GLI2 Mutation (4.51%), GLI2 A780V (0.05%), GLI2 A117T (0.05%), GLI2 R473H (0.05%), and GLI2 E1455K (0.03%) [3].

GLI2 GENIE Cases - Top Alterations

Significance of GLI2 in Diseases

Medulloblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Central Nervous System Embryonal Neoplasm +

Large Cell/Anaplastic Medulloblastoma +

Desmoplastic/Nodular Medulloblastoma +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Anaplastic Oligodendroglioma +

Atypical Teratoid/Rhabdoid Tumor +

High-Grade Glioma, NOS +

Diffuse Midline Glioma, H3 K27M-Mutant +

Anaplastic Astrocytoma +

Malignant Glioma +

Diffuse Glioma +

Glioblastoma +

Ependymoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma, RELA Fusion-Positive +

Intracranial Primitive Neuroectodermal Neoplasm +

Pineoblastoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.