Overview

Location [1]
17q24.1
Pathway
G-protein signaling
Protein [2]
Guanine nucleotide-binding protein subunit alpha-13
Synonyms [1]
G13

Guanine nucleotide binding protein (G protein), alpha 13 (GNA13) is a gene that encodes a protein that functions in transmembrane signal transduction. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and cancers of the urinary tract.

GNA13 is altered in 1.09% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, breast invasive ductal carcinoma, follicular lymphoma, colon adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

GNA13 GENIE Cases - Top Diseases

The most common alterations in GNA13 are GNA13 Amplification (0.50%), GNA13 E311* (0.06%), GNA13 R103Q (0.18%), GNA13 R260* (0.07%), and GNA13 X187_splice (0.07%) [3].

GNA13 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.