Overview

Location [1]
Xq26.2
Protein [2]
Secreted glypican-3
Synonyms [1]
SDYS, SGB, DGSX, GTR2-2, OCI-5, SGBS, SGBS1, MXR7

Glypican 3 (GPC3) is a gene that encodes a protein that may function in the control of cell division and growth regulation. Missense mutations, synonymous mutations, nonsense mutations, and inframe deletions are observed in cancers such as skin cancer, endometrial cancer, and colon cancer.

GPC3 is altered in 0.01% of all cancers.

The most common alteration in GPC3 is GPC3 Amplification (0.00%) [3].

GPC3 GENIE Cases - Top Alterations

Significance of GPC3 in Diseases

Hepatocellular Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Hepatoblastoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.