Overview

Location [1]
16p13.2
Protein [2]
Glutamate receptor ionotropic, NMDA 2A
Synonyms [1]
NR2A, EPND, FESD, LKS, GluN2A, NMDAR2A

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) is a gene that belongs to the glutamate-gated ion channel protein family. The protein functions in synaptic transmission in the neuronal system. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

GRIN2A is altered in 3.64% of all cancers with cutaneous melanoma, lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

GRIN2A GENIE Cases - Top Diseases

The most common alterations in GRIN2A are GRIN2A Mutation (3.41%), GRIN2A Amplification (0.23%), GRIN2A Loss (0.06%), GRIN2A G1322E (0.05%), and GRIN2A E962K (0.04%) [3].

GRIN2A GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.