Overview

Location [1]
3q13.33
Pathway
Beta-Catenin/WNT signaling
Protein [2]
Glycogen synthase kinase-3 beta
Synonyms [1]
-

Glycogen synthase kinase 3 beta (GSK3B) is a gene that encodes a protein that functions as a serine/threonine kinase. The protein is involved in processes such as metabolic regulation, neuronal cell development, and body pattern formation. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

GSK3B is altered in 0.62% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

GSK3B GENIE Cases - Top Diseases

The most common alterations in GSK3B are GSK3B Mutation (0.48%), GSK3B Amplification (0.09%), GSK3B Loss (0.04%), GSK3B R354* (0.02%), and GSK3B R113H (0.01%) [3].

GSK3B GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.