Overview

H3F3C is altered in 1.19% of all cancers with lung adenocarcinoma, testicular mixed germ cell tumor, breast invasive ductal carcinoma, colon adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

The most common alterations in H3F3C are H3F3C Amplification (0.72%), H3F3C Loss (0.04%), H3F3C R52C (0.02%), H3F3C A47V (0.02%), and H3F3C E97K (0.02%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.