Associated Genetic Biomarkers
Hes-related family bHLH transcription factor with YRPW motif 1 (HEY1) is a gene that encodes a nuclear protein that functions as a transcriptional repressor. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, and in-frame deletions are observed in cancers such as liver cancer, lung cancer, and skin cancer.
HEY1 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains HEY1 status as an inclusion criterion, 1 is phase 2 (1 open).
The most frequent alteration to serve as an inclusion eligibility criterion is HEY1-NCOA2 Fusion .
Significance of HEY1 in Diseases
Mesenchymal Chondrosarcoma +
HEY1 is an inclusion criterion in 1 clinical trial for mesenchymal chondrosarcoma, of which 1 is open and 0 are closed. Of the trial that contains HEY1 status and mesenchymal chondrosarcoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.