Overview

Location [1]
7q21.11
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Hepatocyte growth factor beta chain
Synonyms [1]
HGFB, F-TCF, SF, DFNB39, HPTA

Hepatocyte growth factor (HGF) is a gene that encodes a protein that is involved in cell growth, motility, and morphogenesis. The protein, also known as hepatocyte growth factor, functions through the activation of a tyrosine kinase signaling pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as lung cancer, parathyroid cancer, and skin cancer.

HGF is altered in 1.98% of all cancers with lung adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, colon adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

HGF GENIE Cases - Top Diseases

The most common alterations in HGF are HGF Mutation (1.25%), HGF Amplification (0.19%), HGF E199K (0.03%), HGF Loss (0.03%), and HGF E174K (0.01%) [3].

HGF GENIE Cases - Top Alterations

Significance of HGF in Diseases

Melanoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Ovarian Carcinoma +

Bladder Carcinoma +

Malignant Solid Tumor +

Glioblastoma +

Squamous Cell Lung Carcinoma +

Glioma +

Breast Carcinoma +

Sarcoma +

Pancreatic Carcinoma +

Anaplastic Astrocytoma +

Diffuse Intrinsic Pontine Glioma +

Head And Neck Carcinoma +

Lymphoma +

Medulloblastoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.