Overview

Location [1]
7q21.11
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
DFNB39, HGFB, HPTA, F-TCF, SF

Hepatocyte growth factor (HGF) is a gene that encodes a protein that is involved in cell growth, motility, and morphogenesis. The protein, also known as hepatocyte growth factor, functions through the activation of a tyrosine kinase signaling pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as lung cancer, parathyroid cancer, and skin cancer.

Significance of HGF in Diseases

Anaplastic Astrocytoma +

Bladder Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Diffuse Intrinsic Pontine Glioma +

Glioblastoma +

Glioma +

Head And Neck Carcinoma +

Lymphoma +

Malignant Solid Tumor +

Medulloblastoma +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.