Overview

Location [1]
6p22.2
Protein [2]
Histone H1.2
Synonyms [1]
H1s-1, H1C, H1F2, H1.2

Histone cluster 1, H1c (HIST1H1C) is a gene that encodes a protein that belongs to the histone H1 family. The protein binds to linker DNA between nucleosomes that form chromatin fibers. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, frameshift deletions, and in-frame deletions are observed in cancers such as breast cancer, intestinal cancer, and pituitary cancer.

HIST1H1C is altered in 1.04% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, diffuse large B-cell lymphoma, not otherwise specified, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

HIST1H1C GENIE Cases - Top Diseases

The most common alterations in HIST1H1C are HIST1H1C Amplification (0.16%), HIST1H1C Loss (0.07%), HIST1H1C A197_K201del (0.02%), HIST1H1C N77del (0.02%), and HIST1H1C E115K (0.02%) [3].

HIST1H1C GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.