Overview

HIST1H3A is altered in 0.40% of all cancers with breast invasive ductal carcinoma, prostate adenocarcinoma, lung adenocarcinoma, squamous cell lung carcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

The most common alterations in HIST1H3A are HIST1H3A Amplification (0.13%), HIST1H3A Loss (0.08%), HIST1H3A P31A (0.01%), HIST1H3A M1? (0.01%), and HIST1H3A S88P (0.01%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.