Overview

Location [1]
6p22.2
Synonyms [1]
H3/l, H3FL

Histone cluster 1, H3b (HIST1H3B) is a gene that encodes a protein that functions as a core component of the nucleosome. The protein plays an important role in transcriptional regulation, DNA replication, and chromosomal stability. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as breast cancer, lung cancer, and skin cancer.

HIST1H3B is altered in 0.81% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, bladder urothelial carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

HIST1H3B GENIE Cases - Top Diseases

The most common alterations in HIST1H3B are HIST1H3B Mutation (0.57%), HIST1H3B Amplification (0.15%), HIST1H3B Loss (0.08%), HIST1H3B K28M (0.04%), and HIST1H3B E74Q (0.03%) [3].

HIST1H3B GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.