Associated Genetic Biomarkers
Associated Diseases


Location [1]
Synonyms [1]
H3.1, H3/c, H3FC

HIST1H3C is altered in 0.60% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, squamous cell lung carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

HIST1H3C GENIE Cases - Top Diseases

The most common alterations in HIST1H3C are HIST1H3C Amplification (0.11%), HIST1H3C Loss (0.07%), HIST1H3C E98K (0.01%), HIST1H3C E106K (0.01%), and HIST1H3C R130C (0.01%) [3].

HIST1H3C GENIE Cases - Top Alterations

Significance of HIST1H3C in Diseases

Diffuse Midline Glioma, H3 K27M-Mutant +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.